Spray Drying of Amifostine

Amifostine is a cytoprotective agent used to reduce side effects of cancer therapies. Spray drying enables the production of stable, patient-friendly powders with optimized particle properties and bioavailability. It supports oral formulations with controlled release for improved therapeutic outcomes. Application Note No. 427 provides starting parameters, formulations, and results, including Amifostine/PLGA concentrations and solvent systems.

Amifostine/PLGA样品浓度（0.4:1.0和1:1），Amifostine（400mg/1ml或1000mg/2ml）在去离子水中，并在含有1克PLGA的50毫升二氯甲烷中乳化。溶剂中的水中Amifostine，DCM载体中的PLGA，Filmogen Poly（DL-乳酸-羟基乙酸）PLGA 50:50（RG 502；固有粘度0.2 dL/g），磷脂酰胆碱（表面活性剂）。