End point determination for a manifold set up in L-300
End point determination for a manifold set up in Lyovapor™ L-300 Pro by pressure difference test and pressure rise test
In this application note two processes analytical techniques – comparative pressure measurement (pressure difference test) and pressure rise test – were used to determine the endpoint of primary drying of mannitol solutions in the laboratory freeze-dryer Lyovapor™ L-300. The freeze-drying was performed in round bottom flasks using a manifold setup. The analytical techniques can assist the visual control by users to assess the dryness of the sample. By this mean, freeze-drying can be ended precisely leading to shorter process time and reliable drying results.
