Spray drying of paracetamol with the Nano Spray Dryer B-90
Spray drying is a scalable, rapid and drying is a scalable, rapid, and economic technique that allows that converting liquids into dry powders. Paracetamol (also known drug for fever reduction and pain relief with anti-inflammatory effects. In this study, the feasibility of the Nano Spray Dryer B-90 to spray dry paracetamol in combination with Kollidon® 30, a widely applied 30, a widely applied excipient in the excipient in the pharmaceutical and cosmetic industry, was tested. The investigations focused on the influence on particle size, residual solvent content, and morphology.
Einsatz organischer Lösungsmittel in Laborgefriertrocknern
Freeze-dryers were initially intended to be used with water as a solvent. With new applications, freeze-drying is consequently being used more and more in combination with organic solvents instead of water. Organic solvents and inorganic acids and bases are often used in research and development prior to lyophilisation of the sample. The behavior of these new types of samples during freeze-drying must therefore be considered prior to the process.