Freeze drying of Pharmaceutical Ingredients
BUCHI Lyovapor™ L-250 Basic is applied in freeze drying active pharmaceutical compounds dissolved in organic solvent mixtures.
Given the temperature sensitivity of the samples, freeze-drying is used as a safe and effective method to remove moisture, enabling longer preservation. These techniques are crucial for maintaining the structural integrity of sensitive compounds and ensuring compliance with regulatory standards.
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Freeze-dryers were initially intended to be used with water as a solvent. With new applications, freeze-drying is consequently being used more and more in combination with organic solvents instead of water. Organic solvents and inorganic acids and bases are often used in research and development prior to lyophilisation of the sample. The behavior of these new types of samples during freeze-drying must therefore be considered prior to the process.