Spray Drying of Sodium Diclofenac

Spray drying is a common technique used to produce dry powders from liquid drugs, such as sodium diclofenac, for improved handling, storage, and transport. Sodium diclofenac is a non-steroidal anti-inflammatory drug used to relieve pain and inflammation in conditions such as arthritis and menstrual cramps.

The spray drying process involves atomizing a solution of sodium diclofenac in a solvent into a fine mist, which is then rapidly dried in a stream of hot air. The resulting dry powder consists of small, spherical particles with controlled size and shape. The process allows for the production of a large quantity of uniform particles with excellent flowability and dispersion properties.

The properties of the sodium diclofenac powders produced by spray drying can be tailored by adjusting the process parameters, such as the inlet temperature, feed rate, and drying time. The use of different solvents or drying aids can also affect the properties of the final powder.

Overall, spray drying is an effective method for producing sodium diclofenac powders with controlled properties, which can improve the drug's bioavailability and patient compliance. The process allows for the production of a large quantity of uniform particles with excellent flowability and dispersion properties, which can enhance the drug's performance and efficacy.

Please find starting parameters and some Results in this Application Note.