Spray Drying of Amifostine
Amifostine is a cytoprotective agent used to reduce side effects of cancer therapies. Spray drying enables the production of stable, patient-friendly powders with optimized particle properties and bioavailability. It supports oral formulations with controlled release for improved therapeutic outcomes. Application Note No. 427 provides starting parameters, formulations, and results, including Amifostine/PLGA concentrations and solvent systems.
Konsentrasi sampel Amifostin/PLGA (0,4:1,0 dan 1:1), Amifostin (400mg/1ml atau 1000 mg/2ml) dalam air de-ionisasi dan diemulsikan dalam 50 mL diklorometana yang mengandung 1 g PLGA. Pelarut Amifostin dalam Air, PLGA dalam Pembawa DCM, Filmogen Poli (asam DL-laktat-glikolat) PLGA 50:50 (RG 502; viskositas intrinsik 0,2 dL/g), Fosfatidilkolin (Surfaktan).
