Spray Drying of Amifostine
Amifostine is a cytoprotective agent used to reduce side effects of cancer therapies. Spray drying enables the production of stable, patient-friendly powders with optimized particle properties and bioavailability. It supports oral formulations with controlled release for improved therapeutic outcomes. Application Note No. 427 provides starting parameters, formulations, and results, including Amifostine/PLGA concentrations and solvent systems.
Concentrazione del campione Amifostina/PLGA (0,4:1,0 e 1:1), Amifostina (400mg/1ml o 1000 mg/2ml) in acqua deionizzata ed emulsionata in 50 mL di diclorometano contenente 1 g di PLGA. Solvente Amifostina in Acqua, PLGA in Portatore DCM, Filmogeno Poli (acido DL-lattico-glicolico) PLGA 50:50 (RG 502; viscosità intrinseca 0,2 dL/g), Fosfatidilcolina (Surfattante).
