Operational quality performance Check: Nitrogen determination in reference substance

Performance check with a reference substance is a key element in qualifying a distillation unit in an operational qualification (OQ) procedure. To verify the Kjel Line and MultiDist instruments the nitrogen content of dry ammonium dihydrogen phosphate monobasic is determined according to Kjeldahl method. Direct distillation with the steam distillation unit MultiDist was followed by boric acid titration on the Metrohm Eco Titrator. Alternatively, manual titration with/without a titrator could also be performed to quantify the distilled Nitrogen content.

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