Spray Drying of Tuberculosis vaccine
Spray drying has been investigated as a method for producing a stable and effective tuberculosis vaccine. The tuberculosis vaccine, also known as Bacille Calmette-Guérin (BCG), is a live attenuated vaccine that is currently the only vaccine available for preventing tuberculosis. However, BCG has several limitations, including its variability in efficacy and stability.
The spray drying process involves atomizing a BCG vaccine solution into a spray of fine droplets, which are dried by hot air to produce a dry powder. The resulting powder is stable at room temperature and can be stored for extended periods without losing its efficacy.
Spray drying of tuberculosis vaccine offers several advantages, including improved stability, enhanced product uniformity, and reduced manufacturing costs. The process parameters can be optimized to control the particle size, morphology, and chemical composition of the resulting powder, which can be tailored to meet specific product requirements.
Overall, spray drying is a promising method for producing a stable and effective tuberculosis vaccine that can be used in various global health initiatives.
Please find starting paramters and some Results in this Application Note.
