Spray Drying of Paracetamol
Spray drying is a process used to transform a liquid into a dry powder form. Paracetamol (acetaminophen) is a widely used analgesic and antipyretic drug used to treat pain and fever. Spray drying of paracetamol has been studied as a means of improving the drug's solubility, bioavailability, and stability.
The process of spray drying involves atomizing a solution of paracetamol into a stream of hot gas, which evaporates the solvent and leaves behind a fine powder. The resulting paracetamol powder is highly dispersible and can be easily formulated into various dosage forms such as tablets, capsules, or oral suspensions.
Spray drying of paracetamol has been used in a variety of applications, including the production of fast-dissolving tablets, orodispersible films, and orally disintegrating tablets. The process has also been used to improve the stability of paracetamol and to reduce the drug's gastrointestinal side effects.
In summary, spray drying of paracetamol is a promising technology that has the potential to improve the efficacy, safety, and convenience of this widely used analgesic and antipyretic drug. Its applications extend to many different areas of drug delivery, including fast-dissolving dosage forms and orally disintegrating tablets.
Please see the application note for starting paramters, formulations and some results.
