Spray drying of paracetamol with the Nano Spray Dryer B-90
Spray drying is a scalable, rapid and drying is a scalable, rapid, and economic technique that allows that converting liquids into dry powders. Paracetamol (also known drug for fever reduction and pain relief with anti-inflammatory effects. In this study, the feasibility of the Nano Spray Dryer B-90 to spray dry paracetamol in combination with Kollidon® 30, a widely applied 30, a widely applied excipient in the excipient in the pharmaceutical and cosmetic industry, was tested. The investigations focused on the influence on particle size, residual solvent content, and morphology.
TKN determination in water and wastewater
SpeedDigester K-439, Kjel Line and MultiDist: Steam distillation and Potentiometric determination of Total Kjeldahl Nitrogen (TKN) according to the kjeldahl method in water and wastewater along with determination of Limit of Detection (LOD) and Limit of Quantification (LOQ).
Total sulfur dioxide determination in dried apricots by BUCHI method
MultiDist and BasicDist with BUCHI SO2 glass set: Determination of total sulfur dioxide in dried apricot mousse as a reference sample, bio-apricots & a reference standard sodium metabisulfite by the patented BUCHI Method with iodometric titration.
L’uso di solventi organici nel liofilizzatore da laboratorio
Freeze-dryers were initially intended to be used with water as a solvent. With new applications, freeze-drying is consequently being used more and more in combination with organic solvents instead of water. Organic solvents and inorganic acids and bases are often used in research and development prior to lyophilisation of the sample. The behavior of these new types of samples during freeze-drying must therefore be considered prior to the process.
Determinazione dell'azoto nei peptidi attivi farmaceutici
La determinazione dell'azoto e delle proteine totali nei prodotti farmaceutici è descritta nei capitoli della Farmacopea Europea (Ph.Eur.) 2.5.9 e 2.5.33, metodo 7 [1, 2]. Nella farmacopea degli Stati Uniti (USP), la determinazione dell'azoto è descritta nel capitolo 461 [3]. Qui vengono specificate diverse tecniche di titolazione. La Ph.Eur. utilizza la retro-titolazione ed utilizza il rosso metile come indicatore, mentre l'USP utilizza la titolazione diretta potenziometrica, con l'utilizzo dell'acido borico.