Applicazioni
Your Evaporation Guide – Temperature difference
Achieve higher distillation efficiency when using a rotary evaporator by reading on the impact of temperature differences. There is a direct relationship between the heating bath temperature and the evaporation rate. The more energy applied to the evaporation side, and at the same time removed from the condensation side, the more efficient is the distillation. Furthermore, sufficient cooling as well as an appropriate and stable under pressure are crucial for efficient distillation. On the other hand, the consumption of electrical energy is comparatively greater at higher temperatures. Moreover, some samples are thermo-sensitive, thus exacerbating the circumstances. Therefore the respective parameters have to be fine-tuned to the individual sample and application. The “Delta 20 Rule” is a guideline to compromise between high evaporation output and energy usage. For instance, using the 10/30/50 parameters is appropriate for the evaporation process in order to bring in and to carry off the accumulated energy efficiently.
Spray Drying of Amifostine
Amifostine is a cytoprotective agent used to reduce side effects of cancer therapies. Spray drying enables the production of stable, patient-friendly powders with optimized particle properties and bioavailability. It supports oral formulations with controlled release for improved therapeutic outcomes. Application Note No. 427 provides starting parameters, formulations, and results, including Amifostine/PLGA concentrations and solvent systems.





