Lyophilisation of fresh banana slices

Automatic freeze drying endpoint determination for vials application

Automatic freeze drying endpoint determination for vials application on Lyovapor™ L-300 Pro by pressure difference test, pressure rise test and temperature difference test

Lyophilisation of mannitol and NaCl solutions in serum vials

In this Application Note No. 256/2017 sodium chloride (NaCl) and mannitol are used for freeze drying experiments. The unambiguous crystal structure of NaCl renders this salt a model compound. In contrast, mannitol is well known to crystallize in different polymorphs and it may form hydrates. Nevertheless, mannitol is the most used bulking agent for freeze dried pharmaceutical formulations. The benefits of using mannitol are that it crystallizes during freezing, creates a beautiful cake and permits drying processes at higher product temperatures, thus with higher sublimation rates compared to purely amorphous systems.

Lyophilisation of Traditional Chinese Medicine decoctions

Traditional Chinese Medicines (TCM) are usually prepared by mashing and boiling in water. This process is called decoction. Thereby, health beneficial compounds are extracted from herbal and plant material. If not directly administered, these extracts can be preserved for a longer shelf life using lyophilisation. In this Short Note we highlight the lyophilisation procedure of Tianma Gouteng Yin (TGY), as a TCM model decoction. TGY is a widely used medicine applied to treat Parkinson’s disease (PD) like symptoms. Recently, it has been reported that this TCM decoction exerts neuroprotective effects in animal and cell models of PD.

Lyophilisation of truffles

Truffles are products with limited shelf life and their sensory properties are rapidly lost. Hence, the expensive fungi become less valuable within a few days. Losses of volatile compounds, oxidation and enzymatic reactions are a considerable problem during their storage. Furthermore, the aroma profile is commonly modified as a result of elevated temperature processes or enzymatic reactions. Freeze drying the fungi avoids loss and degradation of volatile compounds due to the low temperatures applied during drying. The aromatic profile of truffles are maintained. Freeze dried truffles can either be rehydrated or directly used in dry form.

End point determination for a manifold set up in L-300

End point determination for a manifold set up in Lyovapor™ L-300 Pro by pressure difference test and pressure rise test

Determination of Polycyclic Aromatic Hydrocarbons in water using SyncorePlus with Solid Phase Extraction (SPE) cover

SyncorePlus Analyst: 

Determination of Polycyclic Aromatic Hydrocarbons in water using SyncorePlus with Solid Phase Extraction (SPE) cover

Extraction of micropollutants from contaminated sediments after heavy rain events

Pressurized solvent extraction (PSE) of contamined sediments as a critical part of aquatic risk accessment

Lyophilisation of apples

Lyovapor™ L-210: Freeze Drying of apples

We developed a freeze-drying method with optimized process time and residual moisture content for apples.

Lyophilisation of strawberries

Lyovapor™ L-200: Freeze Drying of strawberries

We developed a freeze-drying method with optimized process time and residual moisture content for strawberries.

Lyophilization of Giloy stem

In traditional Indian medicine, Giloy is one of the most useful ayurvedic herb. Freeze drying is evaluated as a drying method in order to preserve Giloy properties. Freeze drying is known to be one of the most appropriate method for the preservation of natural and biological materials thanks to the oxygen free environment and the low operating temperatures.