Spray Drying of Ibuprofen
Ibuprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to treat pain, fever, and inflammation. Spray drying is a promising technique for producing ibuprofen powder formulations that can improve the solubility, bioavailability, and stability of the drug.
Spray drying of ibuprofen powders requires careful optimization of several parameters, such as the type and concentration of the excipient, the drying temperature, and the feed rate. The final powder properties such as particle size, morphology, and drug content depend on these parameters.
The applications of spray-dried ibuprofen powder are diverse and include the production of oral solid dosage forms, such as tablets and capsules, as well as topical formulations, such as creams and gels. The use of spray-dried ibuprofen powder can improve the dissolution rate and oral bioavailability of the drug, enhance the stability of the drug in solid dosage forms, and provide a more convenient form of administration.
Overall, spray drying of ibuprofen powder is an important process in the pharmaceutical industry, providing a stable and versatile powder form of the drug with improved functional properties that can be applied in various drug delivery applications.
Please see the application note for starting paramters, formulations and some results.
