Spray Drying of Somatostatine (Vapreotide pamoate)
Somatostatin is a hormone that regulates various physiological functions, including hormone secretion, digestion, and cell proliferation. Vapreotide pamoate is a somatostatin analog that is used for the treatment of acromegaly, neuroendocrine tumors, and other conditions.
Spray drying is a common method for producing dry powders of vapreotide pamoate for improved handling, storage, and transport. The process involves atomizing a solution of the drug in a solvent into a fine mist, which is then rapidly dried in a stream of hot air. The resulting dry powder consists of small, spherical particles with controlled size and shape.
The properties of the vapreotide pamoate powders produced by spray drying can be tailored by adjusting the process parameters, such as the inlet temperature, feed rate, and drying time. The use of different solvents or drying aids can also affect the properties of the final powder.
Overall, spray drying is an effective method for producing vapreotide pamoate powders with controlled properties, which can improve the efficacy and safety of the drug. The process allows for the production of a large quantity of uniform particles with excellent flowability and dispersion properties, which can enhance the bioavailability and stability of the drug.
Please find starting paramters and some Results in this Application Note.
