Amifostine is a cytoprotective drug used in cancer treatment to reduce the toxic effects of radiation and chemotherapy on healthy tissues. Spray drying has been explored as a technique for the production of amifostine powder, offering advantages such as improved stability, ease of formulation, and enhanced patient compliance.
The areas of focus in spray drying of amifostine include optimizing the process parameters, such as the inlet and outlet temperatures, atomizer type, and feed rate, to achieve the desired particle size, morphology, and physicochemical properties of the powder. Additionally, research has been conducted to evaluate the impact of different drying conditions and formulation additives on the stability and bioavailability of the drug.
Moreover, spray drying has been investigated as a method for producing amifostine-based formulations, such as tablets or capsules, for convenient oral administration. These formulations can provide controlled release and improved drug delivery profiles, ensuring optimal therapeutic efficacy.
Overall, spray drying of amifostine offers a promising approach for the production of stable and patient-friendly formulations, allowing for better management of the side effects associated with cancer treatment. This technique enables the development of dosage forms that enhance patient comfort and improve treatment outcomes.
Please see the application note for starting paramters, formulations and some results.
Cosmetic Workflow
The world’s cosmetics market has been in constant evolution for more than ten years and France is a major player in this sector thanks to the brand image and quality it conveys. Despite this marketing advantage, cosmetic companies must be innovative and adapt to the new expectations of consumers, turning towards more "natural" cosmetics. The latter are increasingly concerned by the composition of the products they buy, and gradually reject synthetic ingredients, synonymous in their minds with danger to health and pollution. In order to meet the demands of these emerging trends, the global cosmetics industry is constantly looking for natural alternatives to the conventional ingredients, and to do so, favors the use of sustainable processes that are more respectful of the environment. Technological advances are an undeniable asset in this race for "green optimization". BUCHI has developed equipment allowing the automation and sustainable optimization of several stages in the classic process of developing a natural cosmetic active ingredient.