Spray Drying of Aminosalicylic acid
Spray Drying of Aminosalicylic acid with the Mini Spray Dryer B-290
Aminosalicylic acid (ASA) is an antimicrobial drug primarily used in the treatment of tuberculosis. Spray drying has been explored as a technique for the production of ASA powder, offering advantages such as improved solubility, bioavailability, and stability.
The areas of focus in spray drying of aminosalicylic acid include optimizing the process parameters, such as the inlet and outlet temperatures, atomizer type, and feed rate, to achieve the desired particle size, morphology, and drug loading of the powder. Additionally, research has been conducted to evaluate the impact of different drying conditions and formulation additives on the physical and chemical properties of the powder, such as its crystallinity, dissolution rate, and compatibility with excipients.
Moreover, spray drying has been investigated as a method for producing ASA-based formulations, such as tablets or capsules, for oral administration. These formulations can offer improved drug release profiles, enhanced patient compliance, and better therapeutic outcomes.
Overall, spray drying of aminosalicylic acid offers a promising approach for the production of stable and bioavailable formulations, providing opportunities for improved tuberculosis treatment and patient care.
Please see the application note for starting paramters, formulations and some results.
