Nitrogen determination in dihtheria and tetanus toxoids

KjelMaster System K-375 / K-376, KjelDigester K-449, Scrubber K-415

Nitrogen and total protein determination in pharmaceutical products are described in the European Pharmacopoeia (Ph.Eur.) section 2.5.9 and 2.5.33 method 7 [1, 2]. In the Pharmacopoeia of the United States (USP), nitrogen determination is described in section 461 [3]. Therein, different titration techniques are specified. The Ph.Eur. describes back titration in the presence of the indicator methyl red mixed solution and the USP potentiometric and colorimetric boric acid titration.

Short Note No. 279 Nitrogen determination in diphtheria and tetanus toxoids(pdf)

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