Spray Drying of Tobramycin
Tobramycin is an antibiotic used to treat various bacterial infections, including respiratory tract infections and infections in people with cystic fibrosis. Spray drying is a commonly used method to prepare tobramycin powder formulations for inhalation therapy.
Spray drying involves atomizing a solution of tobramycin in a solvent into a fine mist, which is then dried rapidly in a stream of hot air. The resulting dry powder is composed of small, spherical particles with controlled size and morphology.
The properties of the tobramycin powder produced by spray drying can be optimized by adjusting various process parameters such as inlet temperature, feed rate, and drying time. The use of various excipients or drying aids can also affect the properties of the final powder.
Overall, spray drying is a highly effective method for producing tobramycin powders with optimal properties for inhalation therapy. The process allows for the production of a high quantity of uniform particles with excellent flowability and dispersion properties, which can enhance the delivery and efficacy of the drug.
Please find starting paramters and some Results in this Application Note.
