Spray Drying of Lipid / Polycation / pDNA
Spray drying has been explored as a method for the production of lipid/polycation/pDNA (LPD) nanoparticles for use in gene therapy. LPD nanoparticles are a promising alternative to viral vectors for the delivery of therapeutic genes into cells.
The main areas of spray drying of LPD nanoparticles include the pharmaceutical and biotechnology industries. In the pharmaceutical industry, spray-dried LPD nanoparticles are used as a therapeutic agent for the treatment of genetic disorders, cancers, and other diseases. In the biotechnology industry, spray-dried LPD nanoparticles are used as a research tool for the study of gene function and regulation.
Overall, spray drying of LPD nanoparticles has a specific application in the pharmaceutical and biotechnology industries. The use of spray drying can offer several advantages such as improved stability, reproducibility, and scalability, making it a preferred technique for the production of LPD nanoparticles in these industries. However, the optimization of the LPD formulation and the characterization of the spray-dried nanoparticles are significant challenges that need to be addressed for the wider adoption of spray-dried LPD nanoparticles in industry.
