Spray Drying of Mesalazine or Aminosalicylic Acid
Mesalazine (also known as 5-aminosalicylic acid) is a medication used to treat inflammatory bowel disease, such as ulcerative colitis and Crohn's disease. Spray drying has been used to produce mesalazine in powder form, allowing for improved storage, handling, and ease of use.
Spray drying of mesalazine involves atomizing a solution of the drug into a stream of hot gas, which evaporates the solvent and leaves behind a fine powder. The resulting powder has a controlled particle size distribution and improved solubility, making it easier to dissolve and absorb in the body.
The spray-dried mesalazine powder is used in the production of tablets, capsules, and suspensions for oral administration. The powder form allows for precise dosing and improved patient compliance, as it can be easily mixed with food or drink. The improved solubility also allows for more efficient absorption and distribution of the medication in the body.
In summary, spray drying of mesalazine allows for the production of a fine powder form of the medication, which improves its storage, handling, and ease of use. The spray-dried powder is used in the production of oral medications for the treatment of inflammatory bowel disease, improving dosing accuracy and patient compliance.
Please see the application note for starting paramters, formulations and some results.
