Spray Drying of Antibody (anti-IgE Ab)
Spray Drying of Antibody (anti-IgE Ab) with the Mini Spray Dryer B-290
Spray drying has been explored as a technique for the production of antibody (anti-IgE Ab) powders, offering advantages such as improved stability, ease of formulation, and enhanced shelf life. Anti-IgE antibodies are therapeutically important for treating allergic conditions such as asthma and allergic rhinitis.
The areas of focus in spray drying of anti-IgE antibodies include optimizing the process parameters, such as the inlet and outlet temperatures, atomizer type, and feed rate, to achieve the desired particle size, morphology, and preservation of antibody activity. Additionally, research has been conducted to evaluate the impact of different drying conditions and formulation additives on the physical and chemical properties of the powder, such as its reconstitution properties, immunological activity, and long-term storage stability.
Moreover, spray drying has been investigated as a method for producing antibody-based dry powder inhalers, which can be used for targeted delivery to the respiratory system. These inhalable powders offer controlled release and improved bioavailability of the anti-IgE antibodies, leading to more effective treatment of allergic conditions.
Overall, spray drying of anti-IgE antibodies offers a promising approach for the production of stable and bioactive antibody powders, providing opportunities for their use in the development of innovative therapeutic formulations for allergic diseases.
Please see the application note for starting paramters, formulations and some results.
