Spray Drying of Theophiline
Theophylline is a medication commonly used to treat respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Spray drying is one of the methods used to prepare theophylline for oral administration. This process involves the conversion of theophylline powder into a fine spray-dried powder that is more easily absorbed by the body.
The spray-drying process involves the atomization of theophylline solution into droplets, which are then dried by a stream of hot air, resulting in the formation of a fine powder. The properties of the spray-dried theophylline powder, such as particle size, morphology, and crystallinity, are affected by several factors, including the drying temperature, feed rate, and solution concentration.
The spray-dried theophylline powder has improved flowability, dissolution rate, and bioavailability compared to theophylline powder obtained through other methods. The spray-drying method is also scalable, making it a feasible method for the large-scale production of theophylline powder for oral administration.
Please find starting paramters and some Results in this Application Note.
