Spray Drying of Budesonide
Spray Drying of Budesonide with the Mini Spray Dryer B-290
Budesonide is a corticosteroid medication used to treat asthma, allergic rhinitis, and inflammatory bowel disease. Spray drying is a common technique used to convert the liquid form of budesonide into a dry powder, which can be used for inhalation delivery to the lungs, providing a more targeted and efficient treatment.
The areas of focus in spray drying of budesonide include optimizing the process parameters, such as inlet temperature, outlet temperature, atomizer type, feed rate, and solvent composition, to achieve the desired particle size, morphology, and yield. Additionally, research has been conducted to evaluate the impact of different processing aids and excipients on the physical and chemical stability of the budesonide powder, as well as its aerodynamic properties and bioavailability.
Other areas of interest include the development of novel formulations and delivery systems for budesonide powder, such as dry powder inhalers or nebulizers, which can improve its pharmacokinetic and pharmacodynamic properties. Spray drying has also been explored as a potential method for producing budesonide particles with controlled release properties, allowing for sustained drug delivery over a longer period of time. Overall, spray drying of budesonide offers a promising approach for improving the treatment of respiratory and gastrointestinal diseases.
Please see the application note No. 453 for starting parameters, formulations and some results.
