Spray Drying of Chitosan crosslinked and pDNA
Spray Drying of Chitosan crosslinked and pDNA with the Mini Spray Dryer B-290
Spray drying is a commonly used technique in the pharmaceutical industry for the production of dry powders from liquid formulations. Chitosan is a biopolymer that has been extensively studied for its potential applications in drug delivery systems. Crosslinking of chitosan can improve its stability and enhance its properties as a drug carrier.
In recent years, there has been increasing interest in the use of chitosan crosslinked with pDNA (plasmid DNA) for gene delivery applications. Spray drying has been proposed as a potential method for producing chitosan crosslinked with pDNA in a dry powder form.
Several studies have investigated the use of spray drying for the production of chitosan crosslinked with pDNA. The process has been shown to produce stable and highly dispersible powders with good encapsulation efficiency and sustained release properties. The technique has also been used to produce chitosan nanoparticles for gene delivery applications.
Overall, spray drying of chitosan crosslinked with pDNA shows promise as a method for producing dry powders for gene delivery applications. Further research is needed to optimize the process and evaluate the performance of the resulting powders in vivo.
Please see the application note for starting paramters, formulations and some results.
