Spray Drying of Cignolin (Dithranol / Anthralin)
Spray Drying of Cignolin (Dithranol / Anthralin) with the Mini Spray Dryer B-290
Cignolin, also known as dithranol or anthralin, is a drug used to treat psoriasis and other skin conditions. Spray drying is a technique that has been investigated for the production of Cignolin powder, which offers several advantages over other drying methods, such as improved bioavailability, shelf-life, and stability.
The main areas of focus in spray drying of Cignolin include optimizing the process parameters, such as the inlet and outlet temperatures, feed rate, and atomizer type, to achieve the desired particle size, morphology, and drug release properties. Additionally, research has been conducted to evaluate the impact of different excipients, such as polymers and surfactants, on the physical and chemical properties of the powder, such as its solubility, stability, and toxicity.
Furthermore, spray drying has been explored as a method for producing Cignolin-loaded microparticles, which can improve drug targeting and reduce side effects. These microparticles can be used in topical formulations, such as creams, lotions, and gels, for the treatment of psoriasis and other skin diseases. Overall, spray drying of Cignolin offers a promising approach for improving the therapeutic efficacy and patient compliance of this drug.
Please see the application note No. 477 for starting parameters, formulations and some results.
