Spray Drying of Fluticasone propionate
Spray Drying of Fluticasone propionate with the Mini Spray Dryer B-290
Fluticasone propionate (FP) is a corticosteroid used for the treatment of various respiratory and inflammatory diseases, including asthma and chronic obstructive pulmonary disease (COPD). Spray drying of FP involves the atomization of a solution or suspension of the drug in a carrier material, followed by the evaporation of the solvent to produce a dry powder. This process can improve the stability of the drug and enable its formulation into various dosage forms, including inhalation formulations for respiratory delivery. Spray-dried FP has also been studied for its use in combination with other drugs for the treatment of respiratory diseases. For example, the combination of FP with salmeterol, a long-acting beta-agonist, has been formulated into a dry powder inhaler for the treatment of asthma and COPD. Overall, spray drying of FP is a promising approach for the formulation of dry powder dosage forms of the drug, with potential applications in respiratory medicine.
Please see the application note for starting paramters, formulations and some results.
