Penetapan Nitrogen dalam Peptida Aktif Farmasi
Penetapan nitrogen dan total protein dalam produk farmasi dijelaskan dalam Farmakope Eropa (Ph.Eur.) bagian 2.5.9 dan 2.5.33 metode 7 [1, 2]. Dalam Farmakope Amerika Serikat (USP), penetapan nitrogen dijelaskan dalam bagian 461 [3]. Dalam farmakope tersebut, ditetapkan teknik titrasi yang berbeda. Ph.Eur. menjelaskan titrasi balik dengan adanya larutan campuran indikator metil merah dan USP menjelaskan titrasi asam borat potensiometri.
TKN determination in water and wastewater
SpeedDigester K-439, Kjel Line and MultiDist: Steam distillation and Potentiometric determination of Total Kjeldahl Nitrogen (TKN) according to the kjeldahl method in water and wastewater along with determination of Limit of Detection (LOD) and Limit of Quantification (LOQ).
Sulfated Ash Determination for Pharmaceutical Quality Control
The wet digestion is used to remove all carbonous material from the sample. The remaining inorganic content can be weighed out, resulting in the sulfated ash, or then be used for further elemental analysis. The digestion is performed using concentrated sulfuric acid while heating the mixture. The heat is ramped automatically using the BUCHI Wet Digester B-440. Once the sulfuric acid has digested the sample and is evaporated, the sample is eventually ashed in a muffle oven to remove any remaining organic material.