Lyophilisation of mannitol and NaCl solutions in serum vials
In this Application Note sodium chloride (NaCl) and mannitol are used for freeze drying experiments. The unambiguous crystal structure of NaCl renders this salt a model compound. In contrast, mannitol is well known to crystallize in different polymorphs and it may form hydrates. Nevertheless, mannitol is the most used bulking agent for freeze dried pharmaceutical formulations. The benefits of using mannitol are that it crystallizes during freezing, creates a beautiful cake and permits drying processes at higher product temperatures, thus with higher sublimation rates compared to purely amorphous systems.
Spray drying of paracetamol with the Nano Spray Dryer B-90
Spray drying is a scalable, rapid and drying is a scalable, rapid, and economic technique that allows that converting liquids into dry powders. Paracetamol (also known drug for fever reduction and pain relief with anti-inflammatory effects. In this study, the feasibility of the Nano Spray Dryer B-90 to spray dry paracetamol in combination with Kollidon® 30, a widely applied 30, a widely applied excipient in the excipient in the pharmaceutical and cosmetic industry, was tested. The investigations focused on the influence on particle size, residual solvent content, and morphology.